High-amylose sodium carboxymethyl starch matrices for oral, sustained drug release: development of a spray-drying manufacturing process
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چکیده
منابع مشابه
High-amylose carboxymethyl starch matrices for oral sustained drug-release: in vitro and in vivo evaluation.
High-amylose corn starch, that contains 70% of amylose chains and 30% of amylopectin, has been used to obtain substituted amylose (SA) polymers. Tablets have been prepared by direct compression, i.e. dry mixing of drug and SA, followed by compression, which is the easiest way to manufacture an oral dosage form. Until now, their controlled-release properties have been assessed only by an in vitr...
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Substituted amylose (SA) polymers were produced from high-amylose corn starch by etherification of its hydroxyl groups with chloroacetate. Amorphous high-amylose sodium carboxymethyl starch (HASCA), the resulting SA polymer, was spray-dried to obtain an excipient (SD HASCA) with optimal binding and sustained-release (SR) properties. Tablets containing different percentages of SD HASCA and trama...
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ژورنال
عنوان ژورنال: Drug Development and Industrial Pharmacy
سال: 2010
ISSN: 0363-9045,1520-5762
DOI: 10.3109/03639040903517880